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The frontier protein language model lab — simulating 500 million years of evolution
HQ: New York, NY, United States | Founded: 2023 | Employees: ~50 (2026, est.) | Stage: Early Stage VC (Seed/Series A) | Website: https://www.evolutionaryscale.ai
EvolutionaryScale was founded in 2023 by Alexander Rives (CEO), Tom Sercu, and Salvatore Candido — the core research team behind ESM (Evolutionary Scale Modeling), the protein language model family developed at Meta AI that showed language-model-style training could capture the grammar of proteins across billions of sequences. When the team left Meta, they raised the largest seed round in AI-biology history — more than $142M, led by Nat Friedman and Daniel Gross with Lux Capital, Amazon, and NVIDIA — to build the next generation of frontier models for biology.\n\nThe company emerged from stealth in June 2024 with ESM3, a frontier generative model that reasons simultaneously over protein sequence, structure, and function — a genuine advance: ESM3 designed esmGFP, a novel variant of green fl
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