Synthego — Startup Profile

CRISPR genome engineering solutions for life sciences research

HQ: Redwood City, California, USA | Founded: 2012 | Employees: 200-500 | Stage: Late Stage VC | Website: https://www.synthego.com

About

Synthego develops and commercializes CRISPR genome engineering tools, including synthetic guide RNAs, engineered cell lines, and bioinformatics software, enabling researchers in pharmaceutical companies and academic institutions to perform precise gene editing at scale. The company's platform is designed to accelerate drug discovery and therapeutic development workflows by providing standardized, high-quality genome engineering reagents and services. Its product portfolio spans synthetic RNA, cell engineering services, and software tools for CRISPR experiment design and analysis.

The Take

Synthego is a CRISPR genome engineering company that provides synthetic RNA and engineered cell solutions to pharmaceutical and academic researchers, operating in a $150B+ genomics market with modeled unit economics showing a 5x LTV/CAC ratio and 72% gross margins, though the company currently faces a zero-runway situation that raises urgent questions about its near-term viability.

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